Abstract

Background: Cancer remains one of the foremost global causes of mortality, with nearly 10 million deaths recorded by 2020. As incidence rates rise, there is a growing interest in leveraging machine learning (ML) to enhance prediction, diagnosis, and treatment strategies. Despite these advancements, insufficient attention has been directed toward the integration of sociodemographic variables, which are crucial determinants of health equity, into ML models in oncology. Objective: This review aims to investigate how ML techniques have been used to identify patterns of predictive association between sociodemographic factors and cancer-related outcomes. Specifically, it seeks to map current research endeavors by detailing the types of algorithms used, the sociodemographic variables examined, and the validation methodologies used. Methods: We conducted a systematic literature review in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Searches were executed across 6 databases, focusing on the primary studies using ML to investigate the association between sociodemographic characteristics and cancer-related outcomes. The search strategy was informed by the PICO (population, intervention, comparison, and outcome) framework, and a set of predefined inclusion criteria was used to screen the studies. The methodological quality of each included paper was assessed. Results: Out of the 328 records examined, 19 satisfied the inclusion criteria. The majority of studies used supervised ML techniques, with random forest and extreme gradient boosting being the most commonly used. Frequently analyzed variables include age, male or female or intersex, education level, income, and geographic location. Cross-validation is the predominant method for evaluating model performance. Nevertheless, the integration of clinical and sociodemographic data is limited, and Conclusions: ML holds significant potential for discerning patterns associated with the social determinants of cancer. Nevertheless, research in this domain remains fragmented and inconsistent. Future investigations should prioritize the for the development of more equitable, generalizable, and actionable ML applications in cancer care.