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Phenazine 5,10-dioxide derivatives as hypoxic selective cytotoxins: Part II. Structure-activity relationship studies
Keywords: electrochemistry, dna, animals, synthesis, binding, spectrum, cell, design, structure, hypoxia, screening, stress, proton, cytotoxicity, line, resonance, strain, dioxide, vitro, nuclear, interaction, carbon, agent, nitro, drug, quantitative, molecular, article, antineoplastic, analysis, activity, cytotoxins, magnetic, controlled, animal, potentiometry, oxidative, chloroacetamide, cytotoxic, relation, study, 1, v, relationship, derivative, priority, cyclic, in, nonhuman, journal, Structure-Activity, 2, unclassified, Cricetinae, n, (4, yl], yl), tirapazamine, phenazine, quinoxaline, 5,10, Phenazines, (5,10, 7(8), (1,3, dioxolan, yl)phenazin, nitrophenazin, [5,10, phenylpiperazin, yl)acetamide, 79
Abstract
The synthesis and evaluation as hypoxic selective cytotoxins of new derivatives of 2-amino or 2-hydroxyphenazine 5,10-dioxide are described. The compounds were developed as structural analogs of other bioreductive compounds and its in vitro cytotoxicities on V79 cells under hypoxic and aerobic conditions were determined. To gain insight into its mechanism of action electrochemical behavior, interaction with DNA experiments and QSAR studies were performed. © 2006 Bentham Science Publishers Ltd.
Más información
| Título según SCOPUS: | Phenazine 5,10-dioxide derivatives as hypoxic selective cytotoxins: Part II. Structure-activity relationship studies |
| Título de la Revista: | MEDICINAL CHEMISTRY |
| Volumen: | 2 |
| Número: | 5 |
| Editorial: | BENTHAM SCIENCE PUBL LTD |
| Fecha de publicación: | 2006 |
| Página de inicio: | 511 |
| Página final: | 521 |
| Idioma: | eng |
| URL: | http://www.scopus.com/inward/record.url?eid=2-s2.0-33748664599&partnerID=q2rCbXpz |
| DOI: |
10.2174/157340606778250207 |
| Notas: | SCOPUS |