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Solvent-free microwave synthesis of 3-(4-benzo[b]-thiophene-2-carbonyl)-1-piperazinyl-1-benzo[b]thiophen-2-YL-1-propanones. New hetero bis-ligands with potential 5-HT1A serotonergic activity
Abstract
A novel series of 2-benzothiophenealkylpiperazine derivatives 11 (a-d) with potential affinity at 5-HT1A serotonin receptors have been synthesized via solvent-free, microwave-promoted Michael addition of benzo[b]thiophene piperazine derivatives 6(a-c) to substituted benzo[b]thiophen-2-yl propenones 10(b,c). © 2008 The Japan Institute of Heterocyclic Chemistry.
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| Título según SCOPUS: | Solvent-free microwave synthesis of 3-(4-benzo[b]-thiophene-2-carbonyl)-1-piperazinyl-1-benzo[b]thiophen-2-YL-1-propanones. New hetero bis-ligands with potential 5-HT1A serotonergic activity |
| Título de la Revista: | HETEROCYCLES |
| Volumen: | 75 |
| Número: | 8 |
| Editorial: | PERGAMON-ELSEVIER SCIENCE LTD |
| Fecha de publicación: | 2008 |
| Página de inicio: | 1913 |
| Página final: | 1929 |
| URL: | http://www.scopus.com/inward/record.url?eid=2-s2.0-54049109725&partnerID=q2rCbXpz |
| Notas: | SCOPUS |