Article
BIOORGANIC AND MEDICINAL CHEMISTRY  (2009)

Molecular encapsulation of 5-nitroindazole derivatives in 2,6-dimethyl-?-cyclodextrin: Electrochemical and spectroscopic studies

Perez-Cruz, F; Jullian C.; Rodriguez J.; Olea Azar C.; Aran V.J.

Keywords: model, spectroscopy, systems, stability, electron, electrochemistry, solubility, cyclodextrin, structure, proton, spin, beta, resonance, agents, delivery, stoichiometry, nuclear, polarography, drug, molecular, article, analysis, microencapsulation, beta-cyclodextrins, amine, magnetic, pulse, differential, 1, 3, derivative, indazole, Electrochemical, 2, 1h, (2, Models,, (3, unclassified, n, dimethyl, methoxy, Trypanocidal, 2,6, [2, [3, isopropyl, indazol, Indazoles, (benzyloxy), morpholinoethyl), morpholineethyl), yl]ethyl], isopropylpropan, yl)ethyl]propan

Abstract

Four different 5-nitroindazole derivatives (1-4) and its inclusion with Heptakis(2,6-di-O-methyl)-?-cyclodextrin (DM?CD) were investigated. The stoichiometric ratios and stability constants describing the extent of formation of the complexes were determined by phase-solubility measurements obtaining in all cases a type-A L diagram. Also electrochemical studies were carried out, where the observed change in the E PC value indicated a lower feasibility of the nitro group reduction. The same behavior was observed in the ESR studies. The detailed spatial configuration is proposed based on 2D NMR methods. These results are further interpreted using molecular modeling studies. The latter results are in good agreement with the experimental data. © 2009 Elsevier Ltd. All rights reserved.

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Título de la Revista: BIOORGANIC AND MEDICINAL CHEMISTRY
Volumen: 17
Número: 13
Editorial: Elsevier
Fecha de publicación: 2009
Página de inicio: 4604
Página final: 4611
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-66449129374&partnerID=q2rCbXpz