Alternative Functions of the BCL-2 Protein Family at the Endoplasmic Reticulum

Rojas-Rivera, D; Caballero, B; Zamorano S.; Lisbona, F; hetz C.

Abstract

Abstract Apoptosis is essential for maintenance of tissue homeostasis and its deregulation results in a variety of disease conditions. The BCL-2 family of proteins is a group of evolutionarily conserved regulators of cell death that comprises both anti- and pro-apoptotic members, that operate at the mitochondrial membrane to control caspase activation. Different BCL-2-related proteins are also located in the endoplasmic reticulum (ER), where important roles in organelle physiology are proposed. Adaptation to ER stress is mediated by the activation of a complex signal transduction pathway known as the unfolded protein response (UPR). Recent reports indicate that the ER stress sensor IRE1α, signals through the formation of a protein complex platform at the ER membrane, here termed the "UPRosome". Alternatively, BCL-2 family members are contained in other multiprotein complexes at the ER that are involved in the control of diverse cellular processes including calcium homeostasis, autophagy and ER morphogenesis. Here we describe the emerging concept that BCL-2 family members are important regulators of essential cellular processes beyond apoptosis. © 2010 Landes Bioscience and Springer Science+Business Media.

Más información

Título según WOS: Alternative Functions of the BCL-2 Protein Family at the Endoplasmic Reticulum
Título según SCOPUS: Alternative functions of the BCL-2 protein family at the endoplasmic reticulum
Título de la Revista: GLIAL CELLS IN HEALTH AND DISEASE OF THE CNS
Volumen: 687
Editorial: SPRINGER INT PUBLISHING AG
Fecha de publicación: 2010
Página de inicio: 33
Página final: 47
Idioma: English
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-77958144582&partnerID=q2rCbXpz
Notas: ISI, SCOPUS