1H and 13C NMR spectral assignments and X-ray crystallography of 4,5,8,12b-TETrahydro-isoindolo[1,2-a]isoquinoline and derivatives

Castro-Castillo, V; Galdamez, A.; Rebolledo-Fuentes, M; Cassels, B.K.

Abstract

12b-Hydroxy-5,6,8,12b-tetrahydroisoindolo[1,2-a]isoquinolin-8-one (4), 5,6,8,12b-tetrahydroisoindolo[1,2-a]isoquinoline (5) and 12b-hydroxy-5,6,8,12b- tetrahydroisoindolo[1,2-a]isoquinoline (6) were obtained by reduction of 4,5,8,12b-tetrahydroisoindolo[1,2-a]isoquinolin-8-one (3) with LiAlH 4/THF/N 2. The precursor and products were characterized by NMR spectroscopy and the X-ray crystal structure of 5 hydrochloride monohydrate (5a) was determined. 1H and 13C NMR spectra were completely assigned for compounds 3, 4, and 5a, using two-dimensional experiments (H-H COSY, HMQC, HMBC and H-H NOESY).

Más información

Título de la Revista: Journal of the Chilean Chemical Society
Volumen: 57
Número: 1
Editorial: SOC CHILENA QUIMICA
Fecha de publicación: 2012
Página de inicio: 972
Página final: 976
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84864415089&partnerID=q2rCbXpz