Abstract

Pharmacokinetic variables of propofol were studied in 8 foals. Plasma levels of propofol at different time after a single intravenous dose of 2.4 mg/kg bw, were determined by HPLC. An open two compartments model was used to evaluate plasma levels of propofol and values of t(1/2)alpha, t(1/2)beta Vd(c), Vd(ss), Vd beta, Cl-total y MRT were obtained. Propofol pharmacokinetic disposition showed a rapid distribution and removal from organic tissues, and the reported pharmacokinetic variables contribute to determine the appropriate dose to be given.