Abstract

"The synthesis of N,N',N""-tris-(2,3-dihydroxybenzoyl)-1,1,1-tris-(aminomethyl)ethane (11) from 1,1,1-tris-(hydroxymethyl)ethane (1) via the tris-azide 3 is described. Reduction of 3 with lithium aluminium hydride led to the corresponding amine 4 in 65% yield. Acylation of 3 with N-(2,3-dibenzyloxybenzoyloxy)succinimide (9) followed by catalytic hydrogenation afforded N,N',N""-tris-(2,3-dihydroxybenzoyl)-1,1,1-tris-(aminomethyl)ethane (11) in 57% yield"