Antibacterial Activity and Cytotoxicity of Hydrogel-Nanosilver Composites Based on Copolymers from 2-Acrylamido-2-methylpropanesulfonate Sodium

Valle H.; Rivas B.L; Fernandez, M.; Mondaca M.A.; Aguilar M.R.; Román J.S.

Abstract

In this research, we contributed to the search for potential hydrogel-silver dressings by generating hydrogel-silver nanoparticles (AgNPs) composites prepared by the dipping of the crosslinked hydrogel poly(N-vinylpyrrolidone-co-2-acrylamido-2-methylpropanesulfonate sodium) (1:1) and poly(acrylamide-co-2-acrylamido-2-methylpropanesulfonate sodium) (1:1) into an aqueous suspension of citrate-stabilized AgNPs. The composites obtained were evaluated by an antibacterial activity assay on Staphylococcus aureus and Escherichia coli and subjected to an in vitro cytotoxicity assay for human fibroblasts. The composite formed from the hydrogel poly(N-vinylpyrrolidone-co-2-acrylamido-2-methylpropanesulfonate sodium) with 3 mol % N,N-methylene bisacrylamide showed the highest antibacterial activity and the least cytotoxicity among the composites tested; this makes it an excellent alternative as a potential dressing for the treatment of deep and exudative wounds. (c) 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 39644.

Más información

Título según WOS: Antibacterial Activity and Cytotoxicity of Hydrogel-Nanosilver Composites Based on Copolymers from 2-Acrylamido-2-methylpropanesulfonate Sodium
Título según SCOPUS: Antibacterial activity and cytotoxicity of hydrogel-nanosilver composites based on copolymers from 2-acrylamido-2-methylpropanesulfonate sodium
Título de la Revista: JOURNAL OF APPLIED POLYMER SCIENCE
Volumen: 131
Número: 3
Editorial: Wiley
Fecha de publicación: 2014
Idioma: English
URL: http://doi.wiley.com/10.1002/app.39644
DOI:

10.1002/app.39644

Notas: ISI, SCOPUS