Design, synthesis and cellular dynamics studies in membranes of a new coumarin-based "turn-off" fluorescent probe selective for Fe2+

Garcia-Beltran, O; Mena N.; Yanez, O.; Caballero, J; Vargas V.; Nunez, MT; CASSELS, BK

Abstract

A new coumarin-based 'turn-off' fluorescent probe, 7-(diethylamino)-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2-oxo-2H-chromene-3-carboxamide (AGD) was synthesized. This compound is highly selective for ferrous ions (Fe2+) and can reversibly detect them in aqueous medium. The probe localizes to the cell membrane in living cells, where it can detect changes in Fe2+ concentration. Molecular dynamics (MD) simulations indicate that AGD interacts with the lipid bilayer at the level of the glycerol moieties. (C) 2013 Elsevier Masson SAS. All rights reserved.

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Título según WOS: Design, synthesis and cellular dynamics studies in membranes of a new coumarin-based "turn-off" fluorescent probe selective for Fe2+
Título según SCOPUS: Design, synthesis and cellular dynamics studies in membranes of a new coumarin-based "turn-off" fluorescent probe selective for Fe 2+
Título de la Revista: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volumen: 67
Editorial: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Fecha de publicación: 2013
Página de inicio: 60
Página final: 63
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S0223523413003905
DOI:

10.1016/j.ejmech.2013.06.022

Notas: ISI, SCOPUS