Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases

González, Hugo; Elgueta, Daniela; Montoya, Andro; Pacheco, Rodrigo

Abstract

Neuroinflammation constitutes a fundamental process involved in the progression of several neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis and multiple sclerosis. Microglial cells play a central role in neuroinflammation, promoting neuroprotective or neurotoxic microenvironments, thus controlling neuronal fate. Acquisition of different microglial functions is regulated by intercellular interactions with neurons, astrocytes, the blood-brain barrier, and T-cells infiltrating the central nervous system. In this study, an overview of the regulation of microglial function mediated by different intercellular communications is summarised and discussed. Afterward, we focus in T-cell-mediated regulation of neuroinflammation involved in neurodegenerative disorders. (C) 2014 Elsevier B.V. All rights reserved.

Más información

Título según WOS: Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases
Título según SCOPUS: Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases
Título de la Revista: JOURNAL OF NEUROIMMUNOLOGY
Volumen: 274
Número: 1-2
Editorial: Elsevier
Fecha de publicación: 2014
Página de inicio: 1
Página final: 13
Idioma: English
DOI:

10.1016/j.jneuroim.2014.07.012

Notas: ISI, SCOPUS - ISI