New insights into IGF-1 signaling in the heart

Troncoso R.; Ibarra, C; Vicencio, JM; Jaimovich E.; Lavandero S.

Abstract

Insulin-like growth factor 1 (IGF-1) signaling regulates contractility, metabolism, hypertrophy, autophagy, senescence, and apoptosis in the heart. IGF-1 deficiency is associated with an increased risk of cardiovascular disease, whereas cardiac activation of IGF-1 receptor (IGF-1R) protects from the detrimental effects of a high-fat diet and myocardial infarction. IGF-1R activates multiple pathways through its intrinsic tyrosine kinase activity and through coupling to heterotrimeric G protein. These pathways involve classic second messengers, phosphorylation cascades, lipid signaling, Ca2+ transients, and gene expression. In addition, IGF-1R triggers signaling in different subcellular locations including the plasma membrane, perinuclear T tubules, and also in internalized vesicles. In this review, we provide a fresh and updated view of the complex IGF-1 scenario in the heart, including a critical focus on therapeutic strategies.

Más información

Título según WOS: New insights into IGF-1 signaling in the heart
Título de la Revista: TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volumen: 25
Número: 3
Editorial: ELSEVIER SCIENCE LONDON
Fecha de publicación: 2014
Página de inicio: 128
Página final: 137
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S1043276013002075
DOI:

10.1016/j.tem.2013.12.002

Notas: ISI