The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism

Cisternas P.; Silva-Alvarez, C; Martinez F.; Fernandez, E; Ferrada, L.; Oyarce, K; Salazar, K.; Bolanos, JP; Nualart, F.

Abstract

We proposed that the ascorbic acid (AA) taken up by neurons is rapidly oxidized to dehydroascorbic acid (DHA), which inhibits glycolysis and activates the pentose phosphate pathway (PPP), consequently producing NADPH, a critical antioxidant in the recycling of oxidized glutathione (GSSG). In these metabolic conditions, neurons increase lactate uptake, probably using it as an energy source. This data supported the idea that DHA could play a critical role in the modulation of energy metabolism in neurons.

Más información

Título según WOS: The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism
Título según SCOPUS: The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism
Título de la Revista: JOURNAL OF NEUROCHEMISTRY
Volumen: 129
Número: 4
Editorial: Wiley
Fecha de publicación: 2014
Página de inicio: 663
Página final: 671
Idioma: English
URL: http://doi.wiley.com/10.1111/jnc.12663
DOI:

10.1111/jnc.12663

Notas: ISI, SCOPUS - ISI