Hepcidin as a central mediator of anemia of chronic diseases associated with obesity

Villarroel P.; Arredondo M.; Olivares M.

Abstract

Recent evidence suggests that obesity-related inflammation may play a central role in hepcidin regulation. Hepcidin is a key regulator of iron homeostasis and has now been suggested as a central mediator of iron metabolism disorders involved in the pathogenesis of anemia of chronic disease. In this review, we focus on subclinical inflammation in obesity and its effect on hepcidin levels, as the most plausible explanation for the relationship between anemia of chronic disease and obesity.

Más información

Título según WOS: Hepcidin as a central mediator of anemia of chronic diseases associated with obesity
Título de la Revista: REVISTA MEDICA DE CHILE
Volumen: 141
Número: 7
Editorial: SOC MEDICA SANTIAGO
Fecha de publicación: 2013
Página de inicio: 887
Página final: 894
Idioma: Spanish
Notas: ISI