Amyloid aggregates: role in protein misfolding disorders

Duran-Aniotz, C; Moreno-Gonzalez, I; Morales R.

Abstract

Misfolding and aggregation of proteins are the main features of a group of diseases termed Protein Misfolding Disorders (PMDs). PMDs include Alzheimer's disease and Transmissible Spongiform Encephalopathies, among many others. The deposition of protein aggregates is the main responsible for tissue damage and the consequent clinical signs generated in such disorders. In this review, we will focus in the role of protein aggregates in these diseases and in the putative mechanisms by which they exert their toxicity.

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Título según WOS: Amyloid aggregates: role in protein misfolding disorders
Título de la Revista: REVISTA MEDICA DE CHILE
Volumen: 141
Número: 4
Editorial: SOC MEDICA SANTIAGO
Fecha de publicación: 2013
Página de inicio: 495
Página final: 505
Idioma: Spanish
Notas: ISI