Abstract

In this work, nanoparticles of polylactide-co-glycolide (PLGA) loaded with florfenicol were developed using the emulsification/diffusion/evaporation method. The influence of method parameters, such as the organic solvent used, temperature of solvent evaporation, type and time of homogenization procedure, lactic fraction of the polymer, were analyzed. The nanoparticles obtained had a monodispersed submicron size distribution (205 +/- 31, 208 +/- 31 nm), a negative zeta potential (-3.37 +/- 6.33, -3.36 +/- 5.90 mV) and an encapsulation efficiency of 8.24 +/- 1.45 %, 10.52 +/- 2.01 % when PLGA 50/50 and 75/25 were used, respectively.