Abstract

Introduction: Few studies have validated the Spanish-language version of the Montreal Cognitive Assessment (MoCA-S) test in Latin American populations. Objetive: To evaluate the psychometric properties and discriminant validity of the MoCA-S in elderly patients in Santiago de Chile. Methods: 172 individuals were grouped according to their clinical diagnosis based on the Clinical Dementia Rating (CDR) scale as follows: amnestic mild cognitive impairment (aMCI; n = 24), non-amnestic MCI (naMCI; n = 24), mild dementia (n = 20), and cognitively normal (n = 104). Participants were evaluated with both the MoCA-S and the Mini-Mental State Examination (MMSE) to determine the discriminant validity of the MoCA-S. Results: Mean age and years of schooling were 73 +/- 6 and 11 +/- 4 years, respectively, with no significant intergroup differences. The MoCA-S displayed good internal consistency (Cronbach's alpha: 0.772), high inter-rater reliability (Spearman correlation coefficient: 0.846; P < .01), and high intra-rater reliability (test-retest reliability coefficient: 0.922; P < .001). The MoCA-S was found to be an effective and valid test for detecting aMCI (AUC = 0.903) and mild dementia (AUC = 0.957); its effectiveness for detecting naMCI was lower (AUC = 0.629). The optimal cutoff points for aMCI and mild dementia were < 21 and < 20, respectively, with sensitivity and specificity rates of 75% and 82% for aMCI and 90% and 86% for mild dementia. The level of education had a great impact on scores: as a result, 2 points were added for patients with less than 8 years of schooling and one point for patients with 8-12 years of schooling (MoCA-S1-2). The MoCA-S1-2 showed significantly greater discriminant validity than the MMSE for differentiating aMCI from dementia. Conclusions: The MoCA-S1-2 is a short, easy-to-use, and useful test for diagnosing aMCI and mild dementia. (C) 2018 Published by Elsevier Espana, S.L.U. on behalf of Sociedad Espanola de Neurologia.