Cross Currents in Protein Misfolding Disorders: Interactions and Therapy

Soto, Claudio; Green, Kristi M.; Morales, Rodrigo

Abstract

Protein Misfolding Disorders (PMDs) are a group of diseases characterized by the accumulation of abnormally folded proteins. Despite the wide range of proteins and tissues involved, PMDs share similar molecular and pathogenic mechanisms. Several epidemiological, clinical and experimental reports have described the co-existence of PMDs, suggesting a possible cross-talk between them. A better knowledge of the molecular basis of PMDs could have important implications for understanding the mechanisms by which these diseases appear and progress and ultimately to develop novel strategies for treatment. Due to their similar molecular mechanisms, common therapeutic strategies could be applied for the diseases in this group.

Más información

Título según WOS: Cross Currents in Protein Misfolding Disorders: Interactions and Therapy
Título de la Revista: CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
Volumen: 8
Número: 5
Editorial: BENTHAM SCIENCE PUBL
Fecha de publicación: 2009
Página de inicio: 363
Página final: 371
DOI:

10.2174/187152709789541998

Notas: ISI