Article ISI SCOPUS
JOURNAL OF NATURAL PRODUCTS  (2001)

Inhibition of Mycobacterium tuberculosis growth by saringosterol from Lessonia nigrescens

Wachter, GA; Franzblau, SG; Montenegro,G.; Hoffmann, JJ; Maiese, WM; Timmermann, BN

Abstract

Assay-guided fractionation of an antitubercular extract obtained from Lessonia nigrescens yielded the phytosterol saringosterol as its active component. No appreciable toxicity against Veto cells was observed for this compound. Saringosterol was also synthesized by oxidation of fucosterol. The MIC values for antitubercular activity of saringosterol and its 24S and 24R epimers were determined as 0.25, 1, and 0.125 ?g/mL.

Más información

Título según WOS: Inhibition of Mycobacterium tuberculosis growth by saringosterol from Lessonia nigrescens
Título según SCOPUS: Inhibition of Mycobacterium tuberculosis growth by saringosterol from Lessonia nigrescens
Título de la Revista: JOURNAL OF NATURAL PRODUCTS
Volumen: 64
Número: 11
Editorial: AMER CHEMICAL SOC
Fecha de publicación: 2001
Página de inicio: 1463
Página final: 1464
Idioma: English
URL: http://pubs.acs.org/doi/abs/10.1021/np010101q
DOI:

10.1021/np010101q
Notas: ISI, SCOPUS