Use of phenotype microarrays to study the effect of acquisition of resistance to antimicrobials in bacterial physiology

Reales-Calderon, Jose A.; Blanco, Paula; Alcalde-Rico, Manuel; Corona, Fernando; Lira, Felipe; Hernando-Amado, Sara; Bernardini, Alejandra; Sanchez, Maria B.; Martinez, Jose L.

Abstract

It is widely accepted that the acquisition of resistance to antimicrobials confers a fitness cost. Different works have shown that the effect of acquiring resistance in bacterial physiology may be more specific than previously thought. Study of these specific changes may help to predict the outcome of resistant organisms in different ecosystems. In addition to changing bacterial physiology, acquisition of resistance either increases or reduces susceptibility to other antimicrobials. In the current article, we review recent information on the effect of acquiring resistance upon bacterial physiology, with a specific focus on studies using phenotype microarray technology. (C) 2016 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

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Título según WOS: ID WOS:000390624400003 Not found in local WOS DB
Título de la Revista: RESEARCH IN MICROBIOLOGY
Volumen: 167
Número: 9-10
Editorial: ELSEVIERRADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
Fecha de publicación: 2016
Página de inicio: 723
Página final: 730
DOI:

10.1016/j.resmic.2016.04.004

Notas: ISI