DC activated via dectin-1 convert Treg into IL-17 producers

Osorio, Fabiola; LeibundGut-Landmann, Salome; Lochner, Matthias; Lahl, Katharina; Sparwasser, Tim; Eberl, Gerard; Reis e Sousa, Caetano

Abstract

Th cells producing IL-17 play a pro-inflammatory role at mucosal surfaces. Treg at the same sites dampen inflammation and prevent immunopathology. Th cells producing IL-17 (Th17) and Treg are thought to be distinct populations defined by expression of the transcription factors ROR-gamma t and Foxp3, respectively. Here, we show that mouse CD25(+)Foxp3(+) Treg can be converted into a hybrid T-cell population characterized by the expression of Foxp3 and ROR-gamma t and the production of IL-17. Conversion was observed upon coculture with DC selectively activated via dectin-1, a C-type lectin receptor involved in fungal recognition, and depended on IL-23 produced by DC. Within the Foxp3(+) population, only Foxp3(+)ROR-gamma t(+) T cells but not Foxp3(+)ROR-gamma t(-)-T cells become Foxp3(+)IL-17(+) T cells. These results indicate that some Foxp3(+) T cells can produce IL-17 while retaining Foxp3 expression and suggest that Treg could play an unexpected pro-inflammatory role in some settings.

Más información

Título según WOS: DC activated via dectin-1 convert Treg into IL-17 producers
Título de la Revista: EUROPEAN JOURNAL OF IMMUNOLOGY
Volumen: 38
Número: 12
Editorial: WILEY-BLACKWELL
Fecha de publicación: 2008
Página de inicio: 3274
Página final: 3281
DOI:

10.1002/eji.200838950

Notas: ISI