Abstract

Purpose: Develop a sparse and locally low rank (LLR) regularized reconstruction to accelerate MR fingerprinting (MRF). Methods: Recent works have introduced low rank reconstructions to MRF, based on temporal compression operators learned from the MRF dictionary. In other MR applications, LLR regularization has been introduced to exploit temporal redundancy in local regions of the image. Here, we propose to include spatial sparsity and LLR regularization terms in the MRF reconstruction. This approach, so called SLLR-MRF, further reduces aliasing in the time-point images and enables higher acceleration factors. The proposed approach was evaluated in simulations, T-1/T-2 phantom acquisition, and in vivo brain acquisitions in 5 healthy subjects with different undersampling factors. Acceleration was also used in vivo to enable acquisitions with higher in-plane spatial resolution in comparable scan time. Results: Simulations, phantom, and in vivo results show that low rank MRF reconstructions with high acceleration factors (<875 time-point images, 1 radial spoke per time-point) have residual aliasing artifacts that propagate into the parametric maps. The artifacts are reduced with the proposed SLLR-MRF resulting in considerable improvements in precision, without changes in accuracy. In vivo results show improved parametric maps for the proposed SLLR-MRF, potentially enabling MRF acquisitions with 1 radial spoke per time-point in approximately 2.6 s (similar to 600 time-point images) for 2 x 2 mm and 9.6 s (1750 time-point images) for 1 x 1 mm in-plane resolution. Conclusion: The proposed SLLR-MRF reconstruction further improves parametric map quality compared with low rank MRF, enabling shorter scan times and/or increased spatial resolution.