Abstract

Multiple Sclerosis (MS) is a chronic demyelinating disease of the Central Nervous System, whose physiopathology is based on processes of deregulation of the immune system, generating inflammation, neurodegeneration; provoking motor, cognitive and neurosychiatric symptoms. Cognitive symptoms comprise between 40 and 70% of MS patients affecting their functionality. Memory impairment is one of the most common cognitive deficits in these patients. This cognitive ability is crucial for guide behavior toward achieving goals. As part of short-term memory, Working Memory (WM) plays an important role in the cognitive process of multiple cognitive functions. The evidence about MS is scarce and contradictory regarding the nature of its cognitive impairment and its evolution. To address this issue, we our aim was to study the neurobiological mechanism underlying WM impairments in MS patients.