How B cells capture, process and present antigens: a crucial role for cell polarity

Yuseff, Maria-Isabel; Pierobon, Paolo; Reversat, Anne; Lennon-Dumenil, Ana-Maria

Abstract

B cells are key components of the adaptive immune response. Their differentiation into either specific memory B cells or antibody-secreting plasma cells is a consequence of activation steps that involve the processing and presentation of antigens. The engagement of B cell receptors by surface-tethered antigens leads to the formation of an immunological synapse that coordinates cell signalling events and that promotes antigen uptake for presentation on MHC class II molecules. In this Review, we discuss membrane trafficking and the associated molecular mechanisms that are involved in antigen extraction and processing at the B cell synapse, and we highlight how B cells use cell polarity to coordinate the complex events that ultimately lead to efficient humoral responses.

Más información

Título según WOS: ID WOS:000320853100008 Not found in local WOS DB
Título de la Revista: NATURE REVIEWS IMMUNOLOGY
Volumen: 13
Número: 7
Editorial: Nature Publishing Group
Fecha de publicación: 2013
Página de inicio: 475
Página final: 486
DOI:

10.1038/nri3469

Notas: ISI