Role of neurotransmitter gases in the control of the carotid body in heart failure

Schultz, Harold D.; del Rio, Rodrigo; Ding, Yanfeng; Marcus, Noah J.

Abstract

The peripheral arterial chemoreflex, arising primarily from the carotid body in most species, plays an important role in the control of breathing and in autonomic control of cardiovascular function. The peripheral chemoreflex is enhanced in heart failure patients and animal models of heart failure and contributes to the sympathetic hyperactivity and breathing instability that exacerbates the progression of the disease. Studies in animal models have shown that carotid body chemoreceptor activity is enhanced under both normoxic and hypoxic conditions in heart failure due to disruption of local mediators that control carotid body function. This brief review highlights evidence that the alterations in the gasotransmitters, nitric oxide, carbon monoxide, and hydrogen sulfide in the carotid body contribute to the exaggerated carotid body function observed in heart failure. (C) 2012 Elsevier B.V. All rights reserved.

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Título según WOS: ID WOS:000311258500012 Not found in local WOS DB
Título de la Revista: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volumen: 184
Número: 2
Editorial: Elsevier
Fecha de publicación: 2012
Página de inicio: 197
Página final: 203
DOI:

10.1016/j.resp.2012.07.010

Notas: ISI