TCICA mediated synthesis of Spirooxindole by Oxidative Rearrangement of Tetrahydro-β-carbolines: Total synthesis of Coerulescine, Elacomine and Horsfiline

Keywords: Trichloroisocyanuric acid, Spirooxindoles, Natuaral alkaloids

Abstract

An efficient protocol has been developed for the synthesis of spirooxindoles via oxidative rearrangement pathway by using TCICA as mild oxidizing reagent. Also, utilized this protocol for total synthesis of natural spirooxindoles Coerulescine, Elacomine and Horsfiline with excellent yields (up to 95%).

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Fecha de publicación: 2020
Año de Inicio/Término: JANUARY 7-10, 2020
URL: https://www.schq.cl/jchq2020/