Trypanosoma cruzi Calreticulin: Immune Evasion, Infectivity, and Tumorigenesis

Ramírez-Toloza G.; Sosoniuk-Roche E.; Valck C.; Aguilar-Guzmán L.; Ferreira V.P.; Ferreira A.

Abstract

To successfully infect, Trypanosome cruzi evades and modulates the host immune response. T. cruzi calreticulin (TcCalr) is a multifunctional, endoplasmic reticulum (ER)-resident chaperone that, translocated to the external microenvironment, mediates crucial host-parasite interactions. TcCalr binds and inactivates C1 and mannose-binding lectin (MBL)/ficolins, important pattern- recognition receptors (PRRs) of the complement system. Using an apoptotic mimicry strategy, the C1-TcCalr association facilitates the infection of target cells. T. cruzi infection also seems to confer protection against tumorigenesis. Thus, recombinant TcCalr has important antiangiogenic properties, detected in vitro, ex vivo, and in ovum, most likely contributing at least in part, to its antitumor properties. Consequently, TcCalr is useful for investigating key issues of host-parasite interactions and possible new immunological/pharmacological interventions in the areas of Chagas' disease and experimental cancer.

Más información

Título según WOS: Trypanosoma cruzi Calreticulin: Immune Evasion, Infectivity, and Tumorigenesis
Título según SCOPUS: Trypanosoma cruzi Calreticulin: Immune Evasion, Infectivity, and Tumorigenesis
Título de la Revista: TRENDS IN PARASITOLOGY
Volumen: 36
Número: 4
Editorial: Cell Press
Fecha de publicación: 2020
Página de inicio: 368
Página final: 381
Idioma: English
DOI:

10.1016/j.pt.2020.01.007

Notas: ISI, SCOPUS