Hepatic stellate cell activation promotes alcohol-induced steatohepatitis through Igfbp3 and SerpinA12

Arab J.P.; Cabrera D.; Sehrawat T.S.; Jalan-Sakrikar N.; Verma V.K.; Simonetto D.; Cao S.; Yaqoob U.; Leon J.; Freire M.; Vargas J.I.; De Assuncao T.M.; Kwon J.H.; Guo Y.; Kostallari E.; et. al.

Abstract

Background & Aims: Steatohepatitis drives fibrogenesis in alcohol-related liver disease. Recent studies have suggested that hepatic stellate cells (HSCs) may regulate the parenchymal cell injury and inflammation that precedes liver fibrosis, although the mechanism remains incompletely defined. Neuropilin-1 (NRP-1) and synectin are membrane proteins implicated in HSC activation. In this study, we disrupted NRP-1 and synectin as models to evaluate the role of HSC activation on the development of steatohepatitis in response to alcohol feeding in mice.

Más información

Título según WOS: Hepatic stellate cell activation promotes alcohol-induced steatohepatitis through Igfbp3 and SerpinA12
Título según SCOPUS: Hepatic stellate cell activation promotes alcohol-induced steatohepatitis through Igfbp3 and SerpinA12
Título de la Revista: JOURNAL OF HEPATOLOGY
Volumen: 73
Número: 1
Editorial: ELSEVIER SCIENCE BV
Fecha de publicación: 2020
Idioma: English
DOI:

10.1016/J.JHEP.2020.02.005

Notas: ISI, SCOPUS