Genetic algorithms for the imitation of genomic styles in protein backtranslation

Moreira, A.

Abstract

Several technological applications require the translation of a protein into a nucleic acid that codes for it ("backtranslation"). The degeneracy of the genetic code makes this translation ambiguous; moreover, not every translation is equally viable. The common answer to this problem is the imitation of the codon usage of the target species. Here we discuss several other features of coding sequences ("coding statistics") that are relevant for the "genomic style" of different species. A genetic algorithm is then used to obtain backtranslations that mimic these styles, by minimizing the difference in the coding statistics. Possible improvements and applications are discussed. © 2004 Elsevier B.V. All rights reserved.

Más información

Título según WOS: Genetic algorithms for the imitation of genomic styles in protein backtranslation
Título según SCOPUS: Genetic algorithms for the imitation of genomic styles in protein backtranslation
Título de la Revista: THEORETICAL COMPUTER SCIENCE
Volumen: 322
Número: 2
Editorial: ELSEVIER SCIENCE BV
Fecha de publicación: 2004
Página de inicio: 297
Página final: 312
Idioma: English
DOI:

10.1016/j.tcs.2004.03.014

Notas: ISI, SCOPUS