Abstract

A new type of aza-analogues of (E)-4-[2-(1-naphthylvinyl)]-1-substituted pyridinium salts (NVP+) has been designed in order to study their in vitro inhibitory activity towards ChAT. A theoretical analysis has been performed and several examples of (E)-1-alkylazolylvinylpyridinium salts have been synthesized. Among them, the indolylvinylpyridinium salt is the only one showing some ChAT inhibition.