Solid phase synthesis of functionalized indazoles using triazenes - scope and limitations

Maria Garcia, Ana; Jung, Nicole; Gil, Carmen; Nieger, Martin; Braese, Stefan

Abstract

Indazoles are important heterocycles as they are a substantial part in many drugs. In this study, we present a modular synthesis of highly substituted indazoles via a strategy on solid supports. The heterocyclic nitrogen atoms originate from diazonium salts, being cleaved from triazene containing resins. The scope and limitations of this process are explored, considering especially the competitive occurrence of triazines and the cleavage of hydrolyzed and traceless side products.

Más información

Título según WOS: ID WOS:000359136500085 Not found in local WOS DB
Título de la Revista: RSC ADVANCES
Volumen: 5
Número: 80
Editorial: ROYAL SOC CHEMISTRY
Fecha de publicación: 2015
Página de inicio: 65540
Página final: 65545
DOI:

10.1039/c5ra09705c

Notas: ISI