Article ISI
BIOORGANIC & MEDICINAL CHEMISTRY  (2010)

New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities

Duque, Maria D.; Camps, Pelayo; Torres, Eva; Valverde, Elena; Sureda, Francesc X.; Lopez-Querol, Marta; Camins, Antoni; Prathalingam, S. Radhika; Kelly, John M.; Vazquez, Santiago

Abstract

The synthesis of several (1,2,3,5,6,7-hexahydro-1,5: 3,7-dimethano-4-benzoxonin-3-yl)amines and related compounds is reported. Several of them display very similar activity to memantine as NMDA receptor antagonists. Several derivatives showed a significant level of trypanocidal activity. (C) 2009 Elsevier Ltd. All rights reserved.

Más información

Título según WOS: ID WOS:000272892100005 Not found in local WOS DB
Título de la Revista: BIOORGANIC & MEDICINAL CHEMISTRY
Volumen: 18
Número: 1
Editorial: PERGAMON-ELSEVIER SCIENCE LTD
Fecha de publicación: 2010
Página de inicio: 46
Página final: 57
DOI:

10.1016/j.bmc.2009.11.017
Notas: ISI