Patent
 (2014)

Método in vitro para modificar el perfil de depleción de células Treg presentes en una población total de esplenocitos de una muestra biológica al aislar, cultivar y exponer los mismos a un medio de ATP y Polimixina B.

Acuña Claudio, Cappelli Claudio, Coddou Claudio, Escobar Alejandro, Imarai Monica, Labra Yohana, Lopez Ximena, Rios Marcelo, Lopez Marcelo.

Keywords: Polymyxin B, Treg, Depletion

Abstract

In vitro method to modify the depletion profile of Treg cells present in a total splenocyte population of a biological sample comprising isolating, cultivating and submitting the splenocytes to a medium comprising ATP and polymyxin B, wherein the splenocytes are submitted to concentrations of polymyxin B in the range of 0.1 μg/ml to 1,000 μg/ml, and combined use of polymyxin B and ATP for the preparation of a medicament useful in the treatment of a tumors or cancer in mammals, wherein the cancer is melanoma.

Más información

Fecha de publicación: 2014
URL: https://patents.google.com/patent/WO2013023319A8/en
DOI:

WO2013023319A8.