Abstract

The present invention relates to a recombinant vaccine against Lawsonia intracellularis, based on a recombinant synthetic chimeric variant of membrane proteins and invasins of said bacteria. In addition, the invention discloses synthetic nucleotide sequences encoding said protein variants, recombinant proteins as such, an expression cassette of said synthetic protein antigens, a transformed cell, and a method for producing said antigens, demonstrating the antigenicity and protective potential thereof against the pathogen Lawsonia intracellularis.