In vivo acute toxicological studies of an antioxidant extract from Mangifera indica L. (Vimang)

Garrido, gabino; Rodeiro, Idania; Hernandez, Ivones; Garcia, Gaston; Perez, Gema; Merino, Nelson; Nunez-Selles, Alberto; Delgado, Rene

Abstract

Mango (Mangifera indica L.) stem bark aqueous extract (MSBE) is a natural product with antioxidant, anti-inflammatory, analgesic, and immunomodulatory effects. Its formulations (e.g., tablets, capsules, syrup, vaginal oval, and suppositories) are known by the brand name of Vimang (R). In view of the ethnomedical, preclinical, and clinical uses of this extract and the necessity to assess its possible toxicological effect on man, a toxicological analysis of a standard extract is reported in this paper. Acute toxicity was evaluated in mice and rats by oral, dermal, and intraperitoneal (i.p.) administration. The extract, by oral or dermal administration, showed no lethality at the limit doses of 2,000 mg/kg body weight and no adverse effects were found. Deaths occurred with the i.p. administration at 200, but not 20 mg/kg in mice. MSBE was also studied on irritant tests in rabbits, and the results showed that it was nonirritating on skin, ocular, or rectal mucosa. The extract had minimal irritancy following vaginal application.

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Título según WOS: ID WOS:000266590400008 Not found in local WOS DB
Título de la Revista: DRUG AND CHEMICAL TOXICOLOGY
Volumen: 32
Número: 1
Editorial: TAYLOR & FRANCIS LTD
Fecha de publicación: 2009
Página de inicio: 53
Página final: 58
DOI:

10.1080/01480540802432551

Notas: ISI