Inhibition of Human P450 Enzymes by Natural Extracts Used in Traditional Medicine

Rodeiro, Idania; Donato, Maria T.; Jimenez, Nuria; Garrido, gabino; Molina-Torres, Jorge; Menendez, Roberto; Castell, Jose V.; Gomez-Lechon, Maria J.

Abstract

Different medicinal plants are widely used in Cuba and Mexico to treat several disorders. This paper reports in vitro inhibitory effects on the P450 system of herbal products commonly used by people in Cuba and Mexico in traditional medicine for decades. Experiments were conducted in human liver microsomes. The catalytic activities of CYPIA1/2, 2136, and 3A4 were measured using specific probe substrates. The Heliopsis longipes extract exhibited a concentration-dependent inhibition of the three enzymes, and similar effects were produced by affinin (an alkamide isolated from the H. longipes extract) and two catalytically reduced alkamides. Mangifera indica L. and Thalassia testudinum extracts, two natural polyphenol-rich extracts, diminished CYPIA1/2 and 3A4 activities, but not the CYP2D6 activity. These results suggest that these herbs inhibit the major human P450 enzymes involved in drug metabolism and could induce potential herbal-drug interactions. Copyright (C) 2008 John Wiley Sons, Ltd.

Más información

Título según WOS: ID WOS:000263318100023 Not found in local WOS DB
Título de la Revista: PHYTOTHERAPY RESEARCH
Volumen: 23
Número: 2
Editorial: Wiley
Fecha de publicación: 2009
Página de inicio: 279
Página final: 282
DOI:

10.1002/ptr.2613

Notas: ISI