Designing active mats based on cellulose acetate/polycaprolactone core/shell structures with different release kinetics

Rojas, Adrian; Velasquez, Eliezer; Piña, Constanza; Galloto, Maria Jose

Keywords: cellulose acetate, electrospinning, Core/shell Structure, Kinetic release

Abstract

Core/shell electrospun mats based on cellulose acetate (CA) and polycaprolactone (PCL) were developed as novel active materials for releasing quercetin (Quer) and curcumin (Cur). The effect of polymeric uniaxial and coaxial electrospun systems and the chemical structures of Quer and Cur on the structural, thermal, and mass transfer properties of the developed mats were investigated. Release modelling indicated that the diffusion of the active agents from the uniaxial PCL fibers was highly dependent on the type of food simulant. Higher diffusion coefficients were obtained for both active agents in acid food simulant due to the higher swelling of the electrospun mats. In addition, CA/PCL coaxial structures slowed down the diffusion of both active agents into both food simulants. CA increased the retention of the active compounds in the polymer structure, resulting in partition coefficients values higher than the values obtained for uniaxial active PCL mats.

Más información

Título de la Revista: CARBOHYDRATE POLYMERS
Volumen: 261
Editorial: Elsevier
Fecha de publicación: 2021
URL: https://doi.org/10.1016/j.carbpol.2021.117849
DOI:

10.1016/j.carbpol.2021.117849

Notas: WOS