Abstract

In the present study, phytochemical analysis, synthesis and characterization of zinc oxide nanoparticles (NG-ZnO NPs) from neem gum as a capping agent. GC-MS analysis confirms the phytochemical oxadiazol-2yl-benzothiazole-(21.5%) on the synthesized ZnO nanoparticles. Various sophisticated analytical instrumentations characterized the morphological and crystalline behaviour of NG-ZnO NPs. The analytical results confirm the spherical crystals of NG-ZnO NPs in size range of 60-80 nm size. The NG-ZnO NPs shown significantly efficient antibacterial and antibiofilm activity againstP.aeruginosaat 100 mu g/mL. Further, in vitro study on human liver cancer cell line (Hep G2) indicated significantly inhibited the cell proliferation at 100 mu g/mL in 24 h. Also, NG-ZnO NPs have also shown potent mosquito larvicidal activity onC. quinquefasciatusat 100 mu g/mL. Based on findings, it is recommended that neem gum capped ZnO NPs is potential nano biomedical agents to be used in new drug formulations.