ELECTROCHEMICAL, ESR, THEORETICAL STUDIES AND in vitro ANTI-T. cruzi ACTIVITY OF 2-ORGANOMETALLIC-5-NITRO-BENZIMIDAZOLES

Germán Barriga-González; Carla Olivares-Petit; Patricia M. Toro; A. Hugo Klahn; Claudio Olea-Azar; Juan D. Maya; Yosselin Huentupil; Rodrigo Arancibia

Keywords: cyclic voltammetry, esr, dft, trypanocidal activity, Organometallic-benzimidazoles, computational calculations

Abstract

"ABSTRACT The bioorganometallic compounds 2-cyrhetrenyl-5-nitro-benzimidazole (Bzn-1) and 2-ferrocenyl-5-nitro-benzimidazole (Bzn-2) have been proposed as potential anti-Trypanosoma cruzi agents. In this regard, electrochemical, electron spin resonance and biological studies were carried out. Cyclic voltammetry experiments showed the generation of nitro anion radical derivatives and a self-protonation process was observed. Nitro anion radicals generated were characterized and analyzed using electron spin resonance spectroscopy. The compounds were tested in vitro against Trypanosoma cruzi (Dm28c strain). Biological evaluation display that 2-cyrhetrenyl-5-nitro-benzimidazole (Bzn-1) was more active than its ferrocene analogue (Bzn-2) and purely organic derivate (Bzn-3), associated with the electron-withdrawing properties of the (η5-C5H4)Re(CO)3 moiety. Finally, theoretical studies were carried out in order to elucidate the correlation between organometallic fragment, nitro-reduction potentials and trypanocidal activity."

Más información

Título según SCIELO: ELECTROCHEMICAL, ESR, THEORETICAL STUDIES AND in vitro ANTI-T. cruzi ACTIVITY OF 2-ORGANOMETALLIC-5-NITRO-BENZIMIDAZOLES
Título de la Revista: Journal of the Chilean Chemical Society
Volumen: 65
Número: 1
Editorial: SOC CHILENA QUIMICA
Fecha de publicación: 2020
Página de inicio: 4692
Página final: 4696
Idioma: en
DOI:

10.4067/S0717-97072020000104692

Notas: SCIELO