Proyecto
 (2021)

Chimeric and pegylated L-asparaginase: study of the conditions of expression, production and purification of an innovative anti-leukemic biopharmaceutical with low immunogenic potential

Pessoa, Adalberto, Iturriaga, Patricio; Uquiche, Edgar; Zamorano, Mauricio; Antileo, Christian; Short, Stephania

Más información

Fecha de publicación: 2021
Objetivos: 1) Optimize culture to produce a chimeric E. coli ASNase in bioreactor; 2) purify and N-terminal PEGylate this ASNase; 3) characterize structure and function; 4) evaluate in vitro cytotoxicity against leukaemic cell lines; and 5) evaluate in vivo in mouse models
Año de Inicio/Término: 2021-2023
Financiamiento/Sponsor: UFRO-FAPESP
Rol del Usuario: COINVESTIGADOR(A)
DOI:

UFRO-FAPESP 2020/06982-3