Article ISI
CHEMICAL COMMUNICATIONS  (2021)

A native mass spectrometry platform identifies HOP inhibitors that modulate the HSP90-HOP protein-protein interaction

Veale, Clinton G. L.; Mateos-Jimenez, Maria; Vaaltyn, Michaelone C.; Muller, Ronel; Makhubu, Matodzi P.; Alhassan, Mahama; Albericio, Fernando; Mackay, C. Logan; Edkins, Adrienne L.; Clarke, David J.

Abstract

Herein we describe a native mass spectromery protein-peptide model as a competent surrogate for the HOP-HSP90 protein-protein interaction (PPI), application of which led to the qualititive identification of two new peptides capable of in vitro PPI disruption. This proof of concept study offers a viable alternative for PPI inhibitor screening.

Más información

Título según WOS: ID WOS:000701964400001 Not found in local WOS DB
Título de la Revista: CHEMICAL COMMUNICATIONS
Volumen: 57
Número: 83
Editorial: ROYAL SOC CHEMISTRY
Fecha de publicación: 2021
Página de inicio: 10919
Página final: 10922
DOI:

10.1039/d1cc04257b
Notas: ISI