fMRI lag structure during waking up from early sleep stages

Alcaide, Santiago; Sitt, Jacobo; Horikawa, Tomoyasu; Romano, Alvaro; Carolina Maldonado, Ana; Ibanez, Agustin; Sigman, Mariano; Kamitani, Yukiyasu; Barttfeld, Pablo

Abstract

The brain mechanisms by which we transition from sleep to a conscious state remain largely unknown in humans, partly because of methodological challenges. Here we study a preexisting dataset of waking up participants originally designed for a study of dreaming (Horikawa, Tamaki, Miyawaki, Kamitani, 2013) and suggest that suddenly awakening from early sleep stages results from a two-stage process that involves a sequence of cortical and subcortical brain activity. First, subcortical and sensorimotor structures seem to be recruited before most cortical regions, followed by fast, ignition-like whole-brain activationdwith frontal regions engaging a little after the rest of the brain. Second, a comparably slower and possibly mirror-reversed stage might take place, with cortical regions activating before subcortical structures and the cerebellum. This pattern of activation points to a key role of subcortical structures for the initiation and maintenance of conscious states. (c) 2021 Elsevier Ltd. All rights reserved.

Más información

Título según WOS: fMRI lag structure during waking up from early sleep stages
Título de la Revista: CORTEX
Volumen: 142
Editorial: ELSEVIER MASSON, CORP OFF
Fecha de publicación: 2021
Página de inicio: 94
Página final: 103
DOI:

10.1016/j.cortex.2021.06.005

Notas: ISI