Levonorgestrel pharmacokinetics in plasma and milk of lactating women who take 1.5 mg for emergency contraception

Gainer E; Massai, R; Lillo, S; Reyes V.; Forcelledo, ML; Caviedes R.; villarroel, c; Bouyer J.

Abstract

Background: Progestin-only methods are among the contraceptive options available for breastfeeding women, however the doses of progestin used in emergency contraception (EC) have not been evaluated in nursing mothers. We therefore investigated the pharmacokinetics of 1.5 mg levonorgestrel (LNG) in lactating women. Methods: Twelve healthy exclusively breastfeeding volunteers received 1.5 mg LNG. Women refrained from nursing for 72 h after dosing and fed their infants with milk frozen beforehand. Serial blood and milk samples were collected for 120 h and assayed for LNG and sex hormone binding globulin. Results: LNG concentrations peaked in plasma and in milk 1-4 h and 2-4 h after dosing, respectively. Concentrations in milk (M) paralleled those in plasma (P) but were consistently lower (mean M:P ratio 0.28). Estimated infant exposure to LNG is 1.6 μg on the day of dosing (1-mu;g in the first 8 h), 0.3 μg on the second day and 0.2 μg on the third day. Conclusions: Nursing mothers may need EC. These results suggest that to limit infant exposure to the period of maximum LNG excretion in milk, mothers should discontinue nursing for at least 8 h, but not more than 24 h, after EC. © The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.

Más información

Título según WOS: Levonorgestrel pharmacokinetics in plasma and milk of lactating women who take 1.5 mg for emergency contraception
Título según SCOPUS: Levonorgestrel pharmacokinetics in plasma and milk of lactating women who take 1.5 mg for emergency contraception
Título de la Revista: HUMAN REPRODUCTION
Volumen: 22
Número: 6
Editorial: OXFORD UNIV PRESS
Fecha de publicación: 2007
Página de inicio: 1578
Página final: 1584
Idioma: English
URL: http://humrep.oxfordjournals.org/lookup/doi/10.1093/humrep/dem034
DOI:

10.1093/humrep/dem034

Notas: ISI, SCOPUS