Jugos de fruta y productos herbáceos como perpetradores de interacciones farmacocinéticas mediadas por enzimas metabolizadoras y transportadores de membrana. Relevancia en clínica

Matías Cortés; Rodrigo Díaz; Samuel Verdugo; Salvador Cabrera; Pablo Torres-Vergara

Abstract

Drug disposition in the human body is strongly influenced by transporters and metabolizing enzymes expressed in key organs including intestine, liver and kidney. Since drugs and chemicals present in foods such as fruit juices and herb-based products are substrates of the above-mentioned proteins, there is a high probability of pharmacokinetic interactions. Findings from preclinical and clinical studies helped to characterize the mechanisms by which the components of fruit juices and herbs act as perpetrators of pharmacokinetic interactions. The aim of this review is to provide an overview of pharmacokinetic fruit juice- and herb-drug interactions that could be relevant in the clinical setting.

Más información

Título según SCIELO: Jugos de fruta y productos herb�ceos como perpetradores de interacciones farmacocin�ticas mediadas por enzimas metabolizadoras y transportadores de membrana. Relevancia en cl�nica
Título de la Revista: REVISTA MEDICA DE CHILE
Volumen: 149
Número: 7
Editorial: SOC MEDICA SANTIAGO
Fecha de publicación: 2021
Página de inicio: 1036
Página final: 1046
Idioma: es
Notas: SCIELO