Abstract

The objective of this narrative review was to analyze the results of the recently published literature on the role of vitamin D and its possible association with the mechanisms of action on COVID-19 in children and adolescents. The following databases were consulted: Medline / Pubmed, CENTRAL, Scopus, SciELO and the Google Scholar search engine in April 2021. The search strategy was carried out combining the use of Boolean operators ("AND", "OR") using the following words: COVID-19; SARS-CoV-2; Vitamin; Vitamin D; Deficiency; Pediatrics. Child; Adolescent. The recommendations of various organizations suggest a supplementation of between 400 to 1.000 IU / day to maintain or obtain a sufficient serum level (> 30 ng / ml) in children and adolescents, the evidence suggesting a possible relationship between insufficiency states (<30 ng / ml) with incidence and evolution of COVID-19. This narrative review concludes that there is a probable association between vitamin D insufficiency with the incidence and evolution of COVID-19, even when these associations are controversial as a result of the scant evidence for the population studied. More randomized clinical trials are required to allow clinical decisions to be made.