An architectural perspective of vitamin D responsiveness

Montecino, M.; Stein, GS; Cruzat F.; Marcellini, S; Stein, JL; Lian, JB; van Wijnen, AJ; Arriagada, G

Abstract

Vitamin D serves as a principal modulator of skeletal gene transcription, thus necessitating an understanding of interfaces between the activity of this steroid hormone and regulatory cascades that are functionally linked to the regulation of skeletal genes. Physiological responsiveness requires combinatorial control where coregulatory proteins determine the specificity of biological responsiveness to physiological cues. It is becoming increasingly evident that the regulatory complexes containing the vitamin D receptor are dynamic rather than static. Temporal and spatial modifications in the composition of these complexes provide a mechanism for integrating regulatory signals to support positive or negative control through synergism and antagonism. Compartmentalization of components of vitamin D control in nuclear microenvironments supports the integration of regulatory activities, perhaps by establishing thresholds for protein activity in time frames that are consistent with the execution of regulatory signaling. © 2006 Elsevier Inc. All rights reserved.

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Título según WOS: An architectural perspective of vitamin D responsiveness
Título según SCOPUS: An architectural perspective of vitamin D responsiveness
Título de la Revista: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volumen: 460
Número: 2
Editorial: Elsevier Science Inc.
Fecha de publicación: 2007
Página de inicio: 293
Página final: 299
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S0003986106005066
DOI:

10.1016/j.abb.2006.12.015

Notas: ISI, SCOPUS