Exploring neurocircuitries of the basal ganglia by intracerebral administration of selective neurotoxins

Herrera-Marschitz, M; Bustamante D.; Morales P.; Goiny, M

Abstract

The detailed anatomy of the monoamine pathways of the rat, first described by the students of Nils-Åke Hillarp in Sweden, provided the basis for a neurocircuitry targeted pharmacology, leading to important therapeutic breakthroughs. Progress was achieved by the introduction of accurate lesion techniques based on selective neurotoxins. Systematic intracerebral injections of 6-hydroxydopamine let Urban Ungerstedt at the Karolinska Institutet, Stockholm, Sweden, to propose the first stereotaxic mapping of the monoamine pathways in the rat brain; and the 'Rotational Behaviour', as a classical model for screening drugs useful for alleviating Parkinson's disease and other neuropathologies. The direction of the rotational behaviour induced by drugs systematically administrated to unilaterally 6-hydroxydopamine-lesioned rats reveals their mechanism of action at dopamine synapses, as demonstrated when rotational behaviour was combined with microdialysis. The model was useful for proposing a role of dopamine receptors in the gating of the flow of information integrated and/or modulated by the basal ganglia, through different efferent pathways; notably the striatopallidal system, via D2 receptors, and the striatonigral system, via D1 receptors. The role of other dopamine receptor subtypes on rotational behaviour has not yet been clarified. © Springer 2007.

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Título según WOS: Exploring neurocircuitries of the basal ganglia by intracerebral administration of selective neurotoxins
Título según SCOPUS: Exploring neurocircuitries of the basal ganglia by intracerebral administration of selective neurotoxins
Título de la Revista: NEUROTOXICITY RESEARCH
Volumen: 11
Número: 03-abr
Editorial: Springer
Fecha de publicación: 2007
Página de inicio: 169
Página final: 182
Idioma: English
Notas: ISI, SCOPUS