Abstract

We report the case of a newborn girl with jaundice due to increased indirect bilirubin with a positive direct antiglobulin test (DAT) and compensated hemolysis. The result of the newborn`s DAT was discrepant with the negative result of the mother's indirect antiglobulin test (IAT). The multiparous mother had a previous history of fetal hydrops miscarriage, with no known cause, and no record of the cause was found at the hospital where she was treated. After referring the mother's and newborn's samples to a reference laboratory, the rare anti-Sc2 alloantibody was identified in the mother's plasma, and in the newborn's eluate. HEA BeadChip genotyping in newborn DNA sample predicted the SC:1,2 phenotype.