SOLUBILIZATION OF DPPC SMALL UNILAMELLAR LIPOSOMES BY SUCROSE ESTERS: A FLUORESCENCE STUDY

Berrios, E.; Zanocco, AL; Lemp E.; Gunther, G.

Abstract

The effect of the microenvironment on the Laurdan fluorescence was employed to study the solubilization mechanism of Dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) small unilamellar vesicles with several sucrose monoesters. The saturation and the solubilization concentrations (C and C ), the ester-DPPC molar ratio (R ) and the bilayer/aqueous partition coefficients (K) were measured by monitoring changes in laurdan generalized polarization for four different alkyl esters of sucrose. All critical concentrations showed linear dependence with DPPC Hposomes concentration. The saturation and the solubilization capacity of this type of surfactant do not show a direct dependence with the length of its alkyl chain. For the studied series the lauryl sucrose derivative is the compound which presents the higher capacity to sat

Más información

Título según WOS: SOLUBILIZATION OF DPPC SMALL UNILAMELLAR LIPOSOMES BY SUCROSE ESTERS. A FLUORESCENCE STUDY
Título según SCOPUS: Solubilization of DPPC small unilamellar liposomes by sucrose esters. A fluorescence study
Título según SCIELO: SOLUBILIZATION OF DPPC SMALL UNILAMELLAR LIPOSOMES BY SUCROSE ESTERS: A FLUORESCENCE STUDY
Título de la Revista: Journal of the Chilean Chemical Society
Volumen: 53
Número: 4
Editorial: SOC CHILENA QUIMICA
Fecha de publicación: 2008
Página de inicio: 1728
Página final: 1731
Idioma: English
DOI:

10.4067/S0717-97072008000400021

Notas: ISI, SCIELO, SCOPUS