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An Efficient Synthesis of 2,3-Diaryl-2-azabicyclooctanones Via BiCl3-Catalysed Three-Component aza Diels-Alder Reaction
Abstract
The first three-component coupling reactions between various anilines (1), benzaldehydes (2), and cyclohexen-2-one (3) were performed under mild conditions (acetonitrile, room temperature, 14 h) in the presence of 20 mol % BiCl3 to obtain new 2,3-diaryl-2-aza[2.2.2]octan-5-ones (4,5) with interesting acetylcholinesterase inhibitory properties. © 2008 Bentham Science Publishers Ltd.
Más información
| Título según WOS: | An Efficient Synthesis of 2,3-Diaryl-2-azabicyclooctanones Via BiCl3-Catalysed Three-Component aza Diels-Alder Reaction |
| Título según SCOPUS: | An efficient synthesis of 2,3-diaryl-2-azabicyclooctanones via BiCl3 catalysed three-component aza Diels-Alder reaction |
| Título de la Revista: | Letters in Organic Chemistry |
| Volumen: | 5 |
| Número: | 7 |
| Editorial: | Bentham |
| Fecha de publicación: | 2008 |
| Página de inicio: | 559 |
| Página final: | 562 |
| Idioma: | English |
| Notas: | ISI, SCOPUS |